Anti-inflammatory, Analgesic, Antipyretic and Gastrointestinal Ulcerogenic Activites of Metabolites of Bermoprofen (AD-1590), a Non-steroidal Anti-inflammatory Agent
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منابع مشابه
Convenient synthesis, anti-inflammatory, analgesic and ulcerogenic activites of some new bis-hydrazones and pyrazole derivatives.
The reaction of acid hydrazides (1a-c) with 2-chloro-1-(4-chlorophenyl)ethanone (2a) or 2-bromo-1-(4-bromophenyl)ethanone (2b) afforded bis-hydrazones 6a-d, while the reaction of la-c with 2-oxo-N-arylpropanehydrazonoyl chlorides (3a,b) furnished N-(aryl)propanehydrazonoyl chlorides 8a-c. The reaction of the latter chlorides with sodium benzenesulfinate furnished sulfones 11a-c. On the other ha...
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Meloxicam is a non steroidal anti-inflammatory drug, used in the treatment of rheumatoid arthritis and oestoarthritis. It is practically insoluble in water leading to poor dissolution, variations in bioavailability and gastric irritation on oral administration. In order to modulate its gastric side effect and to increase aqueous solubility, physical mixture and solid dispersion of the drug were...
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The reason of this study was to evaluate the action of oxidative stress (OS) induced with hydrogen peroxide (H2O2) on the analgesic, antipyretic and anti-inflammatory effects of aspirin in 7-14 day old chicks. H2O2 at 0.5 % v/v in drinking water induced OS in age 7-14 of the chicks when given freshly. The analgesic Median Effective Dose (ED50) and acute Median Lethal Dose (LD50) values of aspir...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1988
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.108.8_788